Book: Diagnostic Surgical Neuropathology by Location

Diagnostic Surgical Neuropathology by Location
By Kenneth B. Fallon

Diagnostic Surgical Neuropathology by Location

Price: $199.95

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Diagnostic Surgical Neuropathology by Location, is a practical guide for all pathologists in their initial, real-time encounters with brain of spinal cord biopsies for the immediate rendering of an intraoperative diagnosis based on the squash preparations of frozen section. The book is organized with a heavy emphasis on neuroanatomic to neuropathologic relationships best defined as a given lesion’s location with regard to its contiguous macroscopic and microscopic environments. The demonstration of the lesion’s macroscopic environment would include corresponding radiographic images, diagrams, and photographs of applicable autopsy teaching specimens for comparison; the microscopic environment would be illustrated by photomicrographs expressly composed in ways to show lesions in relation to contiguous unaffected, non-diseased tissue. The chapters progress from the cranial-to-caudal segments of the neuraxis from brain to spinal cord, respectively. The topics to be included in this book consist of all lesions likely to be encountered in the course of intraoperative neuropathologic consultation; this would encompass both primary and metastatic (secondary) forms of CNS neoplasia, non-neoplastic CNS lesions (for example, demyelinative processes), and CNS infections.

* Introduces neuropathology via neuroanatomic context instead of type of tissue
* The focus on location supports better understanding of the neuropathologic study
* Introduces the benefits of squash preparations for intraoperative assessment of neuropathology specimens


Product Details

  • Original language: English
  • Binding: Hardcover
  • 656 pages

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MCM6

MCM6

Minichromosome maintenance proteins (MCMs) play an essential role in DNA replication and other cellular activities.

The long term risk of tumor recurrence is higher in adamantine epithelioma (AE) than squamous papillary tumor (SP) and it is associated with MCM6 and DNA topoisomerase II alpha expression 1).

MCM6 protein expression in craniopharyngiomas are related to the prognosis of tumor and thus may be useful in predicting the risk of tumor relapse 2).

In a study, Cai et al., analyzed the relationship between MCM mRNA expression and clinical parameters in 325 gliomas, and found that MCM6 presented high expression and was associated with poor survival. Immunohistochemistry analysis of an independent dataset of 423 glioma tissues confirmed the overexpression of MCM6 protein, especially in glioblastomas (GBMs) with shorter overall survival (OS). Importantly, a combination of MCM6 overexpression with IDH1 mutation further improved the prediction of the prognosis of GBMs. Patients with IDH1 mutation and low MCM6 expression exhibited the longest survival, whereas those with high MCM6 expression and wild-type IDH1 showed the shortest. Collectively, the observation indicates that MCM6 is a biomarker for predicting poor prognosis of the patients with glioma 3).

1)

Xu J, Zhang S, You C, Huang S, Cai B, Wang X. Expression of human MCM6 and DNA Topo II alpha in craniopharyngiomas and its correlation with recurrence of the tumor. J Neurooncol. 2007 Jun;83(2):183-9. Epub 2007 Apr 5. PubMed PMID: 17410335.
2)

Xu JG, You C, Wang XJ, Shuai KG, Wang XS. [Expression of minichromosome maintenance protein 6 in craniopharyngioma and its correlation with prognosis]. Sichuan Da Xue Xue Bao Yi Xue Ban. 2007 Jan;38(1):64-7. Chinese. PubMed PMID: 17294730.
3)

Cai HQ, Cheng ZJ, Zhang HP, Wang PF, Zhang Y, Hao JJ, Wang MR, Wan JH. Overexpression of MCM6 predicts poor survival in patients with glioma. Hum Pathol. 2018 May 9. pii: S0046-8177(18)30154-0. doi: 10.1016/j.humpath.2018.04.024. [Epub ahead of print] PubMed PMID: 29753008.

Decision Making in Neurovascular Disease

Decision Making in Neurovascular Disease

List Price: $249.99

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Neurovascular medicine has emerged as an established, semi-independent subspecialty of neurology and neurosurgery. Decision Making in Neurovascular Disease focuses on the challenging process of determining the best approach for managing patients with intracranial atherosclerosis, carotid artery disease, stroke, aneurysms, arteriovenous malformations, arteriovenous fistulae, cavernous malformations, and hypervascular tumors. Leonardo Rangel-Castilla, Robert Spetzler, esteemed coauthors, and an impressive cadre of experts discuss highly divergent modalities including medical management, open cerebrovascular, endovascular, radiosurgery, and combined/multimodality alternatives.

The book is organized into seven sections: Ischemic Stroke and Vascular Insufficiency, Aneurysms – Anterior Circulation, Aneurysms – Posterior Circulation, Aneurysms – Other, Arteriovenous Malformations and Fistula, Cavernous Malformations, and Hypervascular Tumors. Chapters include an introduction, decision-making algorithm, whether to treat, conservative management, anatomical considerations, clinical and imaging evaluation, differential diagnosis, treatment options, images, clinical and radiographic follow-up, and suggested reading.

Key highlights

Simple algorithms accompanying 71 chapters supported by the latest, most updated information in the literature
More than 375 radiologic images help elucidate disease-specific treatment decision making
Step-by-step guidance, clinical pearls, surgical nuances, complication avoidance, and evidence-based outcomes provide in-depth understanding
Point/counterpoint expert commentary on each case provides balanced insights on potential implications of specific treatments
This essential step-by-step book is a must-have for residents and fellows in neurosurgery, neurology, endovascular, interventional radiology, vascular neurology, and neurocritical care, as well as veteran clinicians in these specialties

Echinococcus canadensis

Echinococcus canadensis

The cestode Echinococcus canadensis belongs to the complex Echinococcus granulosus sensu lato. This parasite is a member of Cyclophyllidea which comprise the majority of tapeworms that are of medical importance. Adult E. canadensis parasitise the small intestines of dogs and other canids. The larval stage is one of the causative agents of the serious and life-threatening human disease cystic echinococcosis. E. canadensis has a worldwide distribution.

A study reports mitochondrial gene analysis from 4 Mongolian pediatric cerebral CE cases. Molecular confirmation was obtained for 3 of the 4 cases, with all 3 cases determined to be due to Echinococcus canadensis (G6/G7) infection. None of the cases had other organ involvement. This is only the third report on the molecular identification of the Echinococcus species responsible for Cerebral echinococcosis, and only the second report of E. canadensis (G6/G7) being the causative agent of cerebral CE 1).

1)

Shirmen O, Batchuluun B, Lkhamjav A, Tseveen T, Munkhjargal T, Sandag T, Lkhagvasuren E, Yanagida T, Nishikawa Y, Ito A. Cerebral cystic echinococcosis in Mongolian children caused by Echinococcus canadensis. Parasitol Int. 2018 May 9. pii: S1383-5769(18)30120-X. doi: 10.1016/j.parint.2018.05.006. [Epub ahead of print] PubMed PMID: 29753095.