Selenio y glioma

Selenio y glioma

La administración de selenio es importante ya que los compuestos de selenio pueden afectar el microambiente tumoral y neoangiogénesis en el glioma maligno por inducción de apoptosis y alteración de la expresión de la metaloproteinasa de matriz.

En 1990, Philipov y Tzatchev agregaron tabletas de selenio a la dieta de 15 pacientes con tumores cerebrales malignos. En doce pacientes con glioblastoma multiforme este tratamiento no prolongó la supervivencia postoperatoria 1).


En la publicación de Yakubov et al. sobre el selenio, los resultados se centran en las propiedades antitóxicas y preventivas en cáncer y su implicación en las terapias multimodales actuales, que incluyen temozolomida (Temodal),ciclofosfamida (Endoxan) y cisplatino (DDP, Platiblastin y Platinol).

Arroja luz sobre los efectos secundarios no deseados en quimioterapia y los desarrollos de nuevos agentes quimioterapéuticos combinatorios con compuestos de selenio. Descubrieron que los compuestos de selenio y selenio tienen perfiles de doble acción con efectos directos contra el cáncer e intensificador de la quimioterapia, así como con agentes neuroprotectores y citoprotectores 2).


La Tiorredoxina reductasa (TrxR) como antioxidante que contiene selenio juega un papel clave en la regulación del estado redox intracelular.

ver Selenocisteína.


En un estudio de casos y controles en gliomas, Peeri et al., examinaron las asociaciones de selenio en uñas de los pies y variantes genéticas de la selenoenzima con el riesgo de glioma y la supervivencia del paciente. Se estudiaron un total de 423 variantes genéticas en 29 genes candidatos en la vía selenoenzimática en 1547 casos de glioma y 1014 controles sanos. Las asociaciones genéticas también se examinaron en la cohorte de la UK Biobank compuesta por 313,868 personas con 322 casos de glioma. El selenio de la uña del pie se midió en una subcohorte de 300 casos de glioma y 300 controles de la misma edad del estudio de casos y controles.

Ninguna de las 423 variantes estudiadas se asoció consistentemente con el riesgo de glioma en los estudios de casos y controles y de cohortes. Además, el selenio de la uña del pie en el estudio de casos y controles no tuvo una asociación significativa con el riesgo de glioma (tendencia p = 0,70) o la supervivencia del paciente entre 254 pacientes con tumores de alto grado (tendencia p = 0,70).

El presente estudio no ofrece respaldo para la hipótesis de que el selenio desempeña un papel en la aparición del glioma o en el resultado del paciente 3).

1)

Philipov P, Tzatchev K. Selenium in the treatment of patients with brain gliomas. A pilot study. Zentralbl Neurochir. 1990;51(3):145-6. PubMed PMID: 1965466.
2)

Yakubov E, Buchfelder M, Eyüpoglu IY, Savaskan NE. Selenium action in neuro-oncology. Biol Trace Elem Res. 2014 Dec;161(3):246-54. doi: 10.1007/s12011-014-0111-8. Epub 2014 Aug 28. Review. PubMed PMID: 25164034.
3)

Peeri NC, Creed JH, Anic GM, Thompson RC, Olson JJ, LaRocca RV, Chowdhary SA, Brockman JD, Gerke TA, Nabors LB, Egan KM. Toenail selenium, genetic variation in selenoenzymes and risk and outcome in glioma. Cancer Epidemiol. 2018 May 16;55:45-51. doi: 10.1016/j.canep.2018.05.002. [Epub ahead of print] PubMed PMID: 29777993.

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Book: Diagnostic Surgical Neuropathology by Location

Diagnostic Surgical Neuropathology by Location
By Kenneth B. Fallon

Diagnostic Surgical Neuropathology by Location

Price: $199.95

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Diagnostic Surgical Neuropathology by Location, is a practical guide for all pathologists in their initial, real-time encounters with brain of spinal cord biopsies for the immediate rendering of an intraoperative diagnosis based on the squash preparations of frozen section. The book is organized with a heavy emphasis on neuroanatomic to neuropathologic relationships best defined as a given lesion’s location with regard to its contiguous macroscopic and microscopic environments. The demonstration of the lesion’s macroscopic environment would include corresponding radiographic images, diagrams, and photographs of applicable autopsy teaching specimens for comparison; the microscopic environment would be illustrated by photomicrographs expressly composed in ways to show lesions in relation to contiguous unaffected, non-diseased tissue. The chapters progress from the cranial-to-caudal segments of the neuraxis from brain to spinal cord, respectively. The topics to be included in this book consist of all lesions likely to be encountered in the course of intraoperative neuropathologic consultation; this would encompass both primary and metastatic (secondary) forms of CNS neoplasia, non-neoplastic CNS lesions (for example, demyelinative processes), and CNS infections.

* Introduces neuropathology via neuroanatomic context instead of type of tissue
* The focus on location supports better understanding of the neuropathologic study
* Introduces the benefits of squash preparations for intraoperative assessment of neuropathology specimens


Product Details

  • Original language: English
  • Binding: Hardcover
  • 656 pages

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Developmental Neuropathology

Escourolle & Poirier’s Manual of Basic Neuropathology

Neuropathology: A Reference Text of CNS Pathology, 3e

Greenfield’s Neuropathology, Ninth Edition – Two Volume Set

MCM6

MCM6

Minichromosome maintenance proteins (MCMs) play an essential role in DNA replication and other cellular activities.

The long term risk of tumor recurrence is higher in adamantine epithelioma (AE) than squamous papillary tumor (SP) and it is associated with MCM6 and DNA topoisomerase II alpha expression 1).

MCM6 protein expression in craniopharyngiomas are related to the prognosis of tumor and thus may be useful in predicting the risk of tumor relapse 2).

In a study, Cai et al., analyzed the relationship between MCM mRNA expression and clinical parameters in 325 gliomas, and found that MCM6 presented high expression and was associated with poor survival. Immunohistochemistry analysis of an independent dataset of 423 glioma tissues confirmed the overexpression of MCM6 protein, especially in glioblastomas (GBMs) with shorter overall survival (OS). Importantly, a combination of MCM6 overexpression with IDH1 mutation further improved the prediction of the prognosis of GBMs. Patients with IDH1 mutation and low MCM6 expression exhibited the longest survival, whereas those with high MCM6 expression and wild-type IDH1 showed the shortest. Collectively, the observation indicates that MCM6 is a biomarker for predicting poor prognosis of the patients with glioma 3).

1)

Xu J, Zhang S, You C, Huang S, Cai B, Wang X. Expression of human MCM6 and DNA Topo II alpha in craniopharyngiomas and its correlation with recurrence of the tumor. J Neurooncol. 2007 Jun;83(2):183-9. Epub 2007 Apr 5. PubMed PMID: 17410335.
2)

Xu JG, You C, Wang XJ, Shuai KG, Wang XS. [Expression of minichromosome maintenance protein 6 in craniopharyngioma and its correlation with prognosis]. Sichuan Da Xue Xue Bao Yi Xue Ban. 2007 Jan;38(1):64-7. Chinese. PubMed PMID: 17294730.
3)

Cai HQ, Cheng ZJ, Zhang HP, Wang PF, Zhang Y, Hao JJ, Wang MR, Wan JH. Overexpression of MCM6 predicts poor survival in patients with glioma. Hum Pathol. 2018 May 9. pii: S0046-8177(18)30154-0. doi: 10.1016/j.humpath.2018.04.024. [Epub ahead of print] PubMed PMID: 29753008.

Decision Making in Neurovascular Disease

Decision Making in Neurovascular Disease

List Price: $249.99

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Neurovascular medicine has emerged as an established, semi-independent subspecialty of neurology and neurosurgery. Decision Making in Neurovascular Disease focuses on the challenging process of determining the best approach for managing patients with intracranial atherosclerosis, carotid artery disease, stroke, aneurysms, arteriovenous malformations, arteriovenous fistulae, cavernous malformations, and hypervascular tumors. Leonardo Rangel-Castilla, Robert Spetzler, esteemed coauthors, and an impressive cadre of experts discuss highly divergent modalities including medical management, open cerebrovascular, endovascular, radiosurgery, and combined/multimodality alternatives.

The book is organized into seven sections: Ischemic Stroke and Vascular Insufficiency, Aneurysms – Anterior Circulation, Aneurysms – Posterior Circulation, Aneurysms – Other, Arteriovenous Malformations and Fistula, Cavernous Malformations, and Hypervascular Tumors. Chapters include an introduction, decision-making algorithm, whether to treat, conservative management, anatomical considerations, clinical and imaging evaluation, differential diagnosis, treatment options, images, clinical and radiographic follow-up, and suggested reading.

Key highlights

Simple algorithms accompanying 71 chapters supported by the latest, most updated information in the literature
More than 375 radiologic images help elucidate disease-specific treatment decision making
Step-by-step guidance, clinical pearls, surgical nuances, complication avoidance, and evidence-based outcomes provide in-depth understanding
Point/counterpoint expert commentary on each case provides balanced insights on potential implications of specific treatments
This essential step-by-step book is a must-have for residents and fellows in neurosurgery, neurology, endovascular, interventional radiology, vascular neurology, and neurocritical care, as well as veteran clinicians in these specialties