The effect of renal dysfunction on short-term outcomes after lumbar fusion

Serum creatinine (a blood measurement) is an important indicator of renal health because it is an easily measured byproduct of muscle metabolism that is excreted unchanged by the kidneys. Creatinine itself is produced via a biological system involving creatine, phosphocreatine (also known as creatine phosphate), and adenosine triphosphate (ATP, the body’s immediate energy supply).

If contrast-enhanced computed tomography (CT) or arteriography is planned, it is appropriate to obtain a baseline creatinine concentration.

Patients with low estimated glomerular filtration rate (GFR) and elevated creatinine levels were associated with higher perioperative morbidity 1).


1) Purvis TE, Kessler RA, Boone C, Elder BD, Goodwin CR, Sciubba DM. The effect of renal dysfunction on short-term outcomes after lumbar fusion. Clin Neurol Neurosurg. 2016 Dec 6;153:8-13. doi: 10.1016/j.clineuro.2016.12.002. [Epub ahead of print] PubMed PMID: 27992823.

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